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The role of SNW/SKIP proteins in splicing
Hollá, Sandra ; Novotný, Marian (advisor) ; Kozáková, Eva (referee)
SNW proteins are essential nuclear factors whose name was derived from the conserved motif SNW. They can be found with various representatives across the eukaryotic empire. SNW proteins are involved in regulating many cellular processes - for example regulation of gene expression and cell cycle. By far the most information about the function of human homologue provides SKIP/NCoA-62, which was found in a number of signaling pathways. Yet it is not fully understood the function of SNW proteins. In this work, I would like to focus on the role of SNW proteins in pre-mRNA splicing, particularly in the yeast Saccharomyces cerevisiae, where most results were acquired. Key words: SNW protein, Prp45, splicing pre-mRNA, SKIP/NCoA-62, Prp22
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The role of SNW/SKIP proteins in splicing
Hollá, Sandra ; Novotný, Marian (advisor) ; Kozáková, Eva (referee)
SNW proteins are essential nuclear factors whose name was derived from the conserved motif SNW. They can be found with various representatives across the eukaryotic empire. SNW proteins are involved in regulating many cellular processes - for example regulation of gene expression and cell cycle. By far the most information about the function of human homologue provides SKIP/NCoA-62, which was found in a number of signaling pathways. Yet it is not fully understood the function of SNW proteins. In this work, I would like to focus on the role of SNW proteins in pre-mRNA splicing, particularly in the yeast Saccharomyces cerevisiae, where most results were acquired. Key words: SNW protein, Prp45, splicing pre-mRNA, SKIP/NCoA-62, Prp22
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